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Early CagriSema notes: appetite, sleep, and adding low‑dose MOTS-c

Posted by weekendnate in Weight Loss & Metabolic - 11 points, 3 comments.

4mg once weekly about three weeks ago. For me the appetite drop kicked in around day four – I noticed I was finishing meals earlier and snacking less without forcing it. Sleep tracking showed a slight bump in deep sleep percentage, maybe 5‑10% higher than baseline, though HRV stayed flat.

2 in per week so far. Curious if anyone has tried stacking a low dose of MOTS-c (say 5mg three times weekly) with CagriSema to target visceral fat while keeping muscle. I’m planning to add that next week and will keep tracking weight, waist, and fasting glucose.

Just my own experience, nothing definitive – definitely worth checking bloodwork before stacking anything. Let me know what you’ve seen.

Comments

  • tiredmira: I added 5mg MOTS-c three times a week to my semaglutide routine about two months ago. I didn’t see a big change in weight, but my waist measurement dropped a little over an inch and my fasting glucose felt a touch steadier. Sleep and HRV stayed about the same for me. Basically it felt like a mild complement rather than a game changer. Keep an eye on labs and how you feel, and let us know how the stack goes.
  • weekendnate: Hearing your waist shrank over an inch and glucose steadied gives me hope for the same effect. I’ll log waist and fasting glucose twice weekly once I start the MOTS-c stack and report back.
  • weekendnate: I’ve seen a similar mild effect with MOTS-c alongside CagriSema – waist trimmed a bit and fasting glucose felt smoother, though weight change was minimal. It does seem more of a subtle add‑on than a major shift. Have you noticed any impact on appetite or sleep when stacking?

Community discussion - research and educational context only. Not medical advice.