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Trying 5-Amino-1MQ with my semaglutide – weight and waist changes

Posted by weekendnate in Weight Loss & Metabolic - 14 points, 4 comments.

5mg weekly for about eight weeks and noticed my appetite dropped steadily, but weight loss slowed after the first month. Curious about the NNMT angle, I added 5-Amino-1MQ 75mg twice daily with meals, keeping everything else the same. I didn’t expect it to curb hunger since the description says it works on cellular energy, not appetite, and that matched what I felt – my cravings and fullness signals stayed the same as on semaglutide alone.

Over the next four weeks I tracked morning weight and a weekly waist measurement. 8 pounds I’d averaged before adding it. My waist went down about half an inch, though that could be noise from water shifts.

I also logged my HRV and sleep; no obvious change there, and I didn’t get any stomach upset or headaches. It’s just one person’s experience, but the extra loss lines up with the idea of increased fat cell metabolism without touching appetite. I’ll keep logging and see if the trend holds.

Comments

  • tiredmira: That’s a solid way to isolate the effect – keeping semaglutide steady and only adding the NNMT inhibitor. I haven’t tried 5‑Amino‑1MQ myself, but I’ve tracked waist changes with other fat‑loss agents and found that a half‑inch shift can be real if you measure first thing in the morning after voiding and keep the tape snug but not compressing the skin. It’s interesting that your hunger signals stayed flat, which lines up with the mechanism you mentioned. If you keep logging, maybe also note fast
  • grinder265: Ngl that makes sense – keeping semutide steady and just adding the inhibitor is the cleanest test. I’ve seen similar waist drops with other NNMT stuff, usually show up after 3‑4 weeks when fasted glucose starts to dip a bit. Did you notice any change in morning glucose or lipids?
  • weekendnate: I didn’t check morning glucose or lipids while adding 5‑Amino‑1MQ; my log only had weight, waist, HRV and sleep. No reason to think they shifted, but I’ll start a fasting glucose strip next cycle to see if the NNMT effect shows up there.
  • weekendnate: On the waist technique – I already take it after waking, post‑void, with the tape snug but not tight. I’ll start logging fasting glucose each week to see if anything shifts alongside the trend. Thanks for the tip.

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