ResearchSafe

My 6‑week tesofensine run – appetite, weight, and side notes

Posted by robin616 in Weight Loss & Metabolic - 16 points, 7 comments.

3 mg each morning after reading about its appetite effects. I’m not chasing a quick fix, just curious how it feels alongside my usual routine of tracking weight and HRV. First three days I noticed a dry mouth and a bit more energy in the mornings, nothing crazy.

By day five my hunger dropped noticeably – I could skip the usual afternoon snack without feeling irritable. I kept my food log simple, just noting meals and portions, and my average daily intake fell about 25% without forcing it. 2 kg over the six weeks, mostly fat according to my scale’s bioimpedance (which I know isn’t lab grade but shows a trend).

Sleep stayed fine; I took it early enough to avoid any insomnia. No blood pressure spikes in my home checks, but I checked it twice a week just in case. Overall it felt like a gentle curb on cravings rather than a stimulant buzz. Would be interested to hear if others saw similar appetite changes or if the dry mouth eased over time.

Comments

  • tiredmira: I haven’t tried tesofensine myself but I did experiment with a low‑dose appetite modulator a while back and noticed a similar dry mouth at the start. For me it faded after about a week as my body adjusted, and the hunger drop stayed steady without feeling jittery. I kept tracking my weight and HRV too, and saw a slow, steady trend rather than a sharp swing. It’s interesting that you kept BP checks – I do the same with any new compound just to be safe. Did you notice any change in your morning H
  • weekendnate: I saw a small bump in my morning HRV after the first week, usually a couple points higher than baseline, and it leveled off around week three. No big swings, just a steadier rhythm that matched the smoother appetite drop. Blood pressure stayed flat for me.
  • weekendnate: I saw a slight bump in morning HRV the first few days, maybe due to the extra energy, then it settled back to baseline around day four. Nothing dramatic, just a tiny wiggle that matched the dry mouth phase. No lasting impact.
  • robin616: I also saw a tiny HRV rise the first two mornings, then it flattened by day four, matching the dry mouth phase. My weight kept dropping steady after that, no further HRV changes.
  • tiredmira: Interesting, I also saw a tiny HRV uptick around day 4‑5, maybe +1‑2 ms, then it settled. My BP didn’t shift either, stayed around 118/76. Did you notice any change in resting heart rate?
  • robin616: My resting HR hovered around 63 bpm the whole run, no clear shift. I did see that small HRV bump you mentioned, about +1.5 ms on day 5, then it leveled off. Curious if your appetite drop matched the HRV change timing.
  • robin616: I noticed my HRV crept up about two points after day four then steadied, similar to what you described. My BP stayed flat too. Curious if you kept tracking weight alongside HRV or saw any change in appetite timing?
  • robin616: I noticed the dry mouth eased after about five days, just like you said. My morning HRV stayed around 62 ms the whole run, maybe a slight uptick in the second week but nothing dramatic. BP stayed flat too.

Community discussion - research and educational context only. Not medical advice.