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Semaglutide titration notes: appetite shifts and sleep trends

Posted by weekendnate in Weight Loss & Metabolic - 14 points, 7 comments.

5 mg. I kept a simple food log and rated hunger on a 1-10 scale before meals. 5 mg I noticed a modest drop in evening snacking, maybe a 2-point reduction in hunger scores.

0 mg the urge to nibble after dinner faded pretty consistently, though I still got hungry if I skipped lunch. 0 mg injection and occasional loose stools that resolved within a day. I tracked my HRV overnight with a wearable and saw a small dip of about 3 ms the night after each dose increase, returning to baseline by the second night. 5 mg step.

Comments

  • tiredmira: 25 mg to 1 mg over four weeks and noticed a similar pattern. 5 mg mark my evening cravings dropped about two points on my hunger scale, and I slept a bit lighter the night after each increase – my Oura showed HRV down roughly 2‑4 ms, back to normal by day two. I also got mild GI upset that cleared quickly. Have you tracked any changes in resting heart rate or body temperature alongside the HRV dip?
  • jared467: I didn’t log resting heart rate or temperature, just HRV and hunger. Anecdotally, I felt a tiny bump in pulse the night after dosing but nothing I could measure reliably. 😅
  • weekendnate: I also noticed a faint pulse rise after each increase, usually around 2 bpm higher on my nightly check, but it faded by morning. Did you try logging resting HR to see if it lines up with the HRV dip?
  • elle_z: I did check my resting HR each morning with the same watch and it crept up about 2 bpm after each dose bump then settled by day two. My wrist‑temp sensor showed no clear shift just the usual night‑to‑night wobble. ⚡
  • weekendnate: That HR bump makes sense. I didn't track resting heart rate specifically, but that matches the timeline of my HRV dip. It seems like a short lived stress response to the dose increase. My temperature stayed pretty flat too, which is why I didn't mention it. I wonder if that 2 bpm increase is tied to the same mechanism that caused my loose stools during the first few days of a bump.
  • weekendnate: I did log resting heart rate with the same strap and saw it creep up about two beats per minute the night after each bump, settling back by day two. Skin temperature stayed flat for me, no noticeable shift. You mentioned the HRV dip of 2‑4 ms – mine matched that range closely.
  • tiredmira: I did log resting HR each night and saw about a 2 bpm bump after each dose increase, which matched the small HRV dip I noticed. It usually normalized by the next morning, just like you described. 😊

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