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Amlexanox with low-dose semaglutide, my 4-week notes on appetite and energy

Posted by tiredmira in Weight Loss & Metabolic - 13 points, 5 comments.

25 mg once a week four weeks ago to see if it would help curb my evening snacking. After two weeks with no big change in appetite I added amlexanox 50 mg three times daily with meals. I track my hunger with a simple 0-10 scale each night and my morning HRV to gauge energy.

Basically the first week of semaglutide alone felt like a slight delay in hunger after dinner but I still ate my usual portions. Adding amlexanox seemed to shave off about one point on my hunger score by the third week and I noticed fewer cravings for carbs after lunch. 2 lbs total over the four weeks which is slower than I hoped but my HRV stayed stable and I didn’t get any nausea or GI upset.

Comments

  • elle_z: I've been reading a lot about amlexanox lately but haven't pulled the trigger yet. It's interesting that it helped with the carb cravings specifically. I've struggled with that mid afternoon slump where I just want something sweet, so that part sounds quite shiok ⚡. Do you think the hunger drop was purely from the amlexanox or maybe just the semaglutide finally kicking in? I've heard the titration can be a bit slow for some people. I'm curious if you're planning to stick with 50 mg or if you'll
  • jared467: For me the hunger drop felt more noticeable after I added amlexanox, but semaglutide could have been building too. I kept the dose at 50 mg three times a day and haven’t tried changing timing yet. Skin looked a bit smoother, just my own experience. 🌱
  • tiredmira: That is interesting about your skin. I have not noticed anything there yet, but I will keep an eye on it since that is a nice bonus 🥗. Basically, I am wondering if the timing of the amlexanox matters. You said you just took it three times a day, but did you take it exactly with the meal or a bit after? I am trying to see if that affects the hunger drop.
  • tiredmira: For me the hunger dip showed up only after I added amlexanox, while semaglutide alone just delayed hunger a bit. I'm keeping 50 mg three times a day for now and haven't seen any skin changes yet. 😊
  • weekendnate: I swallowed each 50 mg dose right at the start of breakfast, lunch and dinner, no delay. Didn’t see any skin changes either, just the modest hunger dip you noted.

Community discussion - research and educational context only. Not medical advice.