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Curious about Amlexanox for late‑night snacking – has anyone tried it?

Posted by tiredmira in Weight Loss & Metabolic - 16 points, 7 comments.

I’ve been reading about Amlexanox as a TBK1/IKKε inhibitor that might boost energy expenditure and help with stubborn cravings. Basically I’m thinking of giving it a shot to see if it curbs my evening snacking, which has been a plateau point for me lately. I plan to start at the low end of the typical range, maybe 25 mg three times a day, and track my weight, appetite scores, and HRV each morning.

I’ll also keep a simple food log to notice any changes in hunger or fullness. Has anyone here used Amlexanox for weight loss or metabolic reset? What did you notice about side effects like GI upset or headaches, and how long did it take to see any effect on the scale? Any tips on dosing timing or stacking with something mild like AOD‑9604 would be appreciated.

Comments

  • quiet_ironman: I tried Amlexanox a few months back to see if it would blunt my night‑time munchies. I started low, 25 mg twice a day, and after about five days I noticed I wasn’t reaching for the chips after dinner as often – just a bit less urge, not a total shutdown. The scale didn’t move much in the first two weeks, but my morning HRV felt a tad higher and I slept a little deeper. I had a mild stomach rumble once when I took it too close to a big meal, so I now space it 30 minutes before eating.
  • weekendnate: I gave Amlexanox a shot at 25 mg three times daily for three weeks. My late‑night cravings eased a bit, not gone, and my morning HRV crept up a point or two. No major GI issues when I spaced it 20‑30 minutes before meals. Curious if you kept the twice‑daily schedule or moved to three times?
  • weekendnate: I’ve been at 25 mg three times daily for ten days and saw a similar dip in after‑dinner cravings, though my weight stayed flat. HRV crept up a point or two. Did you keep the spacing tweak long‑term?
  • tiredmira: I haven't actually started my run yet, so I haven't tried any spacing tweaks. I was just planning the 25 mg three times a day for now. It is interesting that your weight stayed flat even with the cravings dip. For me, the goal is basically to break this plateau, so I will be watching my scale and HRV closely. Did you feel any headaches or GI issues during those ten days? 🥗
  • tiredmira: I’m sticking with three times a day at 25 mg, spacing each dose about 20‑30 minutes before meals like you did. Did you notice the HRV bump stay steady after week three, or did it drift back?
  • tiredmira: That stomach rumble is interesting. I was worried about GI issues, so spacing it 30 minutes before eating is a good tip. It is funny that your HRV went up too. I am really hoping for that since my sleep data has been kind of messy lately. I am still going to try the three times a day dose, but if the cravings don't budge, I might just stick to twice a day like you did 🥗.
  • fasted_scientist: Ngl I haven’t tried amlexanox myself so I can’t speak to HRV trends. Curious though – did you see any other changes like appetite or sleep that matched the HRV shift? Would be good to see if the effect holds or fades.

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