PEG-MGF injection site soreness – any tips to reduce it?

Posted by casey613 in Safety & Side Effects - 3 points, 3 comments.

I’ve been trying PEG-MGF for a nagging shoulder impingement that’s lingered since my firefighting days. I’m doing 150 mcg twice a week, subQ in the deltoid area. After the first couple of injections I noticed a pretty noticeable red spot and a dull ache that lasts about a day.

It’s not painful enough to stop me, but it’s annoying and makes me wonder if I’m doing something wrong. Has anyone else run into similar site reactions? I’ve tried rotating to the glute and using a smaller needle, but the redness still pops up.

Would icing the spot right after the injection help, or should I split the dose into smaller amounts and inject more frequently? I haven’t done any bloodwork yet, just going off how I feel, but I’m curious if there’s any known interaction with common NSAIDs like ibuprofen that folks use for the soreness. Any safety tips or harm‑reduction tricks would be appreciated.

Comments

• quiet_ironman: I’ve run into similar redness and a dull ache when I first started PEG‑MGf in my quads, especially if I hit the same spot too often. For me switching to a fresh site each time and using a 29‑g insulin needle helped cut the irritation down a lot. I also let the vial warm to room temp, inject real slow, and then hold a cool (not ice‑cold) compress on the area for a few minutes – that seemed to calm the redness without numbing the tissue too much. Splitting the dose into smaller shots more frequen
• practical_optimizer: Yeah, rotating sites and smaller needle helps. I did the same with BPC-157 but still got redness. Maybe add some light movement post-injection? Like stretching the shoulder? Bascally, if it’s not stopping you, it’s probably fine. 😅 Any other tricks besides the compress?
• casey613: Thanks for the stretching tip, haven’t tried that yet. Rotating sites helped a bit but the redness still pops up even in the glute. Would you do the stretching after the injection or before? Also, does the dose size matter more than frequency? I’m thinking maybe 75 mcg once a week might spread it out, but not sure if that’d help the soreness.
• casey613: Thanks for the tips, trying the 29g needle and warming the vial next time. The compress part’s new to me; how long should i hold it? Also, hasn’t ibuprofen made the redness worse for you? I’m hesitant to take it regularly but might test a small dose post-injection.

Community discussion - research and educational context only. Not medical advice.