ResearchSafe

RU‑58841 with finasteride – any androgenic side effects?

Posted by runner_aaron in Safety & Side Effects - 7 points, 8 comments.

I’ve been using 50 mg RU‑58841 daily on carnival days 1–2 h before grind, and I’ve added a 1 mg finasteride tablet for full‑spectrum DHT blocking. RU‑58841 is local, so I don’t feel any systemic “shrinking” or libido change, but the scalp is a little drier and I've had some mild itching early on. After 4 weeks I still see no hair shedding and the density on the frontal line is steadier.

My question is: have others noticed any unexpected androgenic effects (like increased acne, voice changes, or hormone lab shifts) when stacking the topical anti‑androgen with oral finasteride? I’ve kept my HR and testosterone labs at the clinic and saw no significant drop in free testosterone or any rise in estrogen. I’d love to hear about similar protocols, especially any reports of subtle systemic absorption or any long‑term safety signs from others in the community.

Comments

  • greg208: I’ve never used RU‑58841, but I’ve been on finasteride for a few years with no acne flare or voice changes, just a touch of dry skin on the scalp. The topical part is usually skin‑only, so I’d expect almost no systemic uptake – the packet says it’s pretty local. I’ve seen others complain about mild skin irritation or a rash when they first start, which then subsides. Since you’re checking labs, that’s the right move; keep an eye on free testosterone and estradiol –YPES. Have you had any odd ski
  • grinder265: I’ve only seen the same mild scalp dryness and occasional itching, nothing like acne or voice changes. My libido’s stayed the same over months. Labs back me up, free T and estradiol normal. Any hair density swing you’ve noticed with the stack?
  • rational_nomad: For what it is worth, i’ve never had androgenic side effects from stacking them either. My scalp felt a bit tight at first, but nothing like acne or libido shifts. The local action of the peptide probably keeps systemic effects minimal, which aligns with what i’ve read about its application. Keep checking labs if you’re worried, but my experience has been mostly skin-side stuff.
  • runner_aaron: I also noticed that tight feeling early on, but it faded after a week. Have you kept the stack past four weeks and seen any labs shift? Just curious if the dryness sticks around long‑term.
  • runner_aaron: Lekker to hear your labs stayed normal too. It makes me feel BETTER about the systemic absorption. As for density, the frontal line seems steadier than before, tbh. I haven't seen any major growth yet, but the shedding has basically stopped since I started the stack. I am just hoping it stays this way without the itching getting worse. Have you tried any specific scalp oils to help with that dryness, or just dealt with it?
  • runner_aaron: Tbh, your point about systemic low uptake via topical makes sense, posed the question because others online mention oral use causing weird side effects, but your pack’s warnings align with my no-libido change. On that note, have you seen anyone stack both long-term without weird hairline shifts or lab weirdness? Curious if your 4-week stability holds up past 8 weeks.
  • quiet_ironman: For me, the tightness did ease after a week too, but I’ve stuck with the stack for 6 weeks now, dryness’s still there but less itchy. No lab shifts noticed, but I haven’t tracked bloodwork. Curious if others have checked levels? 🔬
  • grinder265: Ngl I’ve been dabbing a few drops of jojoba oil right after my rinse, lets the scalp stay supple without making the RU feel greasy. It’s cut the itch down a bit, though the dryness still pops up on really long runs. You tried anything else?

Community discussion - research and educational context only. Not medical advice.