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Recent GHRP-2 trial on sleep and recovery – what I think

Posted by vo2max_sleep in Research & News - 8 points, 7 comments.

com/ghrp2-sleep-trial). The authors reported that participants fell asleep faster and felt more rested in the morning, which lines up with the known GH‑releasing action of the peptide. For me, when I’ve used GHRP-2 at 200 mcg before bed I’ve noticed deeper sleep and a bigger appetite the next day, but I also felt a bit more stressed in the evenings – likely the mild cortisol bump mentioned in the description. The trial didn’t measure cortisol or prolactin, so I wonder if those side effects showed up at all.

Comments

  • runner_aaron: Tbh I’ve tried GHRP‑2 100 mcg before bed a few times. Sleep got deeper; I fell asleep quicker and woke up feeling a bit more refreshed. But I also felt a little on edge in the evenings – a autofocus on the cortisol bump some papers hint at. I never checked my cortisol, so I can’t say whether it spiked or not. Anyone else feel that post‑dose tension? If you’ve measured it, what range did you see? Also, I’ve had a slight increase in appetite the next day, so that could be a useful clue. Just my
  • greg208: Not gonna lie, I felt a bit tense too after a 200 mcg dose before bed. I haven’t done any cortisol checks myself, so it’s all just a gut feeling. The extra appetite fits – I’ve seen that too. Anyone else notice a spike in stress or appetite?
  • grinder265: NGL, I’ve been on 200 mcg before bed and felt the same edge thing. It’s probably the cortisol surge people talk about, but I never checked levels. Do any of you have a rough ideaighted range or a method that worked for you? The appetite boost is my cue.
  • vo2max_sleep: I kept it simple – 200 mcg in a syringe, 30 minutes before lights out, on a 4‑week repeat. I logged the next‑morning calories and wrote a short note about how rested I felt, plus a stress score 1‑5. The appetite bump was always on the higher side, about 300‑500 extra kcal breakfast. I didn’t do any lab testing, but my cortisol guess came from feeling the edge described – the evening mood dip. Did you try any dose tweaks or change meal timing to see if the stress edge lessened?
  • vo2max_sleep: Yeah, the 200mcg definitely hits the same spots for me, appetite jump and that evening stress. Since the study didn’t track cortisol, I’m curious if that’s a common thing with GHRP-2 or just us. Have you tried lowering the dose or spacing it out? Might help with the tension without losing the sleep benefits.
  • vo2max_sleep: That edge in the evenings feels real, so I think it is probably the cortisol thing. I use 200 mcg and saw the same, but I never checked cortisol either, just assumed. I noticed the appetite bump the next day too. Did you take it 30 minutes before sleep, or earlier? I’m curious if a lower dose, like 50 mcg, would cut the tension but keep the sleep benefit.
  • greg208: Not gonna lie, lowering it to 150 mcg for me still gave the sleep boost but the stress bit eased a lot. I’ve tried splitting it – 100 mcg half‑night and 100 mcg pre‑bed – and the evening tension seems to drop. Curious if anyone’s seen the same with 200 mcg?

Community discussion - research and educational context only. Not medical advice.