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Seeking feedback on a TB‑500 plus‌మ fragments stack for post‑ACL rehab

Posted by casey613 in Protocols & Stacks - 7 points, 6 comments.

Hey folks, I’ve been using TB‑500 at 2 mg twice a week for the last 4 months after my ACL reconstruction, and the range and flexibility improvements have been steady. Now I’m thinking of adding the shorter fragment, TB‑4‑Frag, at 500 µg daily to target the micro‑damage around the tendon insertion. The idea is to dose TB‑500 at 2 mg in the morning, then give TB‑4‑Frag 4–6 hours later, so the actin‑sequestering signal stays continuous while the fragment’s shorter half‑life lets it hit the micro‑tissue more deeply. I’d also like to add Serrapeptase 10 mg once daily on top of ibuprofen 200 mg at night to help with inflammation.

Comments

  • runner_aaron: Hey, I’ve been on TB‑500 at 2 mg twice weekly for about three months post‑ACL surgery and noticed a gradual improvement in knee bend and less morning stiffness – tbh it could just be the rehab work paying off. Adding TB‑4‑Frag makes sense in theory because the fragment’s shorter half‑life might catch the micro‑tears that the longer‑acting TB‑500 misses, but I wonder if spacing them 4–6 hours apart actually keeps the actin signal continuous or just creates two separate peaks. Have you checked any
  • experiment765: I’ve been doing the same split dosing for a month and just going on how the knee feels – seems a bit smoother but could be placebo, imo. Haven’t run any blood tests, just rehab and feel. What about you?
  • grinder265: I’ve stuck to the 4‑6 hour split myself and it feels more like two separate peaks than a constant actin signal – the TB‑4‑Frag just peaks faster. I haven’t done any blood work; I gauge itponde by pain and range. For Serrapeptase I take it at bedtime with ibuprofen, but I keep an eye on stomach cramps and check my CRP analyzes every few weeks to stay safe.
  • casey613: Thanks for the insight, grinder265. I’ve been following the 4‑6 hour split too, and I agree the TB‑4‑Frag seems to peak faster, so I’ll keep the staggered dosing. I’ll start routine CRP checks like you do. How often did you notice any spikes in CRP or stomach discomfort with the ibuprofen‑serrapeptase combo? Also, do you feel the two peaks help with daily pain?
  • casey613: I’ve been on the split schedule for 4 months now, with TB‑500 2 mg each morning and TB‑4‑Frag 500 µg about 5 h later, and the knee has been feeling smoother – especially the swelling at the tibial insertion went from a 3‑4 on a 0‑4 pain scale to about 1‑2 after 6 weeks. I still haven’t done blood work, so this is still a subjective read. The ibuprofen‑Serrapeptase combo feels clear in the evenings, but I’m wondering if a CRP or ESR check would catch any hidden inflammation?
  • casey613: I haven’t run any blood work yet, just tracking range of motion with my physio notes and how the knee feels during drills – seems steady but could be placebo lah. I take Serrapeptase with my morning TB‑500 dose and ibuprofen only at night before bed, haven’t noticed stomach upset. How’s your serrapeptase timing working out for you?

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