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My first few weeks on low‑dose rapamycin – what I’ve noticed so far

Posted by brett_d in Longevity & Anti-Aging - 13 points, 4 comments.

Hey folks, just thought I’d share a quick log from the past month since I started a low‑dose rapamycin protocol (around 4 mg once a week, taken on a Sunday night). To be fair, I’m still keeping an eye on blood work and have a GP in the loop, but I wanted to put my personal observations out there.

First thing I noticed was a subtle shift in my sleep quality – I tend to fall asleep a bit faster and stay in the deeper stages longer, even though my bedtime routine hasn’t changed. My morning energy feels a touch steadier; I’m not hitting that mid‑morning slump that used to creep in after a heavy breakfast.

On the training side, I’ve been doing three cycling sessions a week (about 45 km each) and haven’t seen any difference in performance, but my recovery feels a little quicker – soreness seems to fade within a day rather than two. My skin has also looked a bit more hydrated, maybe just a coincidence but I’ve had fewer dry patches.

No mouth sores or GI issues yet, which is a relief. I’m planning to keep the once‑weekly schedule for a few more months and will update if anything changes. Anyone else on a similar dose? Curious about any longer‑term tweaks you’ve made. 📚🙂

Comments

  • freya_f: It is great that you are staying on top of your blood work, ngl. That is the only way to really know what is happening under the hood. I had a similar experience with my skin feeling a bit better, though I honestly cannot tell if it was the rapamycin or just the humidity on the coast this month (it has been brutal lately). One thing I learned the hard way is to be really careful about your glucose levels. I noticed my fasting blood sugar crept up a bit during my first few months. I ended up t
  • priya_gains: I’ve seen the same glucose dip when I pair a low‑carb dinner with the Sunday dose – it steadies the fasting numbers for a few days. If you’re not already, I usually aim for under 40 g carbs after 6 pm on the day before, then let my regular diet slide back afterward. Does that fit with what you tried?
  • brett_d: that fits pretty well with what ive been doing, though i havent been quite as strict as 40g. i reckon its helped the glucose side of things, but i mostly just try to keep the carbs low on saturday night to be fair. i might try your specific limit and see if it makes a difference to my fasting numbers. do you find that helps with the morning energy too, or is it just about the blood sugar?
  • brett_d: Fair point about the glucose – I actually saw a tiny rise in my fasting numbers too, though still in the normal range, so I’ve started cutting back on the carb‑heavy pasta night before my Sunday dose. Did you find a specific low‑carb window (like 24 h vs just the meal) made a bigger difference? I’ll keep tweaking and let you know if it steadies things. 🙂

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