ResearchSafe

Nasal irritation with intranasal NA Selank Amidate – how to keep it under control?

Posted by greg208 in Safety & Side Effects - 2 points, 8 comments.

Not gonna lie, I started NA Selank Amidate last month to cut anxiety and it was great, but the nose has been acting up. Every time I spray, I feel a sharp burn and a runny nose that lasts a bit, especially if I use it close to
Sleep. I’ve tried using a different bottle, lowering the dose to the lower end of the 300‑900 µg range, and even waiting a few minutes after each spray, but the irritation never really disappears.

I was wondering if anyone has found a trick – perhaps using a saline rinse before or after, changing the spray pressure, or adding(chat) a mild antihistamine nasal spray to switch it off? Any suggestions on how to keep the benefits without the nose drama?

Comments

  • kayla_s: I’ve been spraying intranasal peptides for a few years, mostly for sleep support, and the irritation you’re describing is pretty common. 9% salt solution. It’s almost like the saline “warms up” the mucosa and the peptide sloughs off a bit easier. I also switched to a device that gives a gentler, slower spray; the pressure on the first few sprays is what usually causes the sting.
  • hank_m: Tbh i’ve been on a similar path with selank once, and the burn was real. I found that using a gentle saline rinse right before each spray actually calmed the irritation for me, and i kept the dose at the lower end of the range, no more than 300 µg Jeux. I also switched to a silicone bottle that gives a slower stream, which cut the sting down a bit. Another trick i tried was a mild antihistamine spray, but i only used it on the day i felt the worst and the runny nose eased. If you’re up for it,
  • hank_m: Tbh i gave that 9 % saline a go, it eased the burn a smidge but the first few sprays still stung, so i switched to a slower‑spray pump like you did, and then mixed the peptide with a tiny drop of saline before spraying – that cut the irritation the most. Do you αλλαγ?
  • ivy_mobility: Thanks for the tips, Hank. I’ve tried the silicone bottle and it helped a bit, Webb. The saline rinse worked for a week but the burn returned once I switched back to my original bottle. I’m still testing the antihistamine spray on just the worst nights to see if it keeps the runny nose in check.
  • greg208: I was chuffed to hear the silicone bottle gave you a bit of relief, ivy. I’ve been using the original glass one, so switching to silicone might cut the burn – I’ll give it a go next week. The saline rinse sounding good for a week but then back again suggests it’s the bottle surface that matters. Have you noticed a difference in runny‑nose severity when you add the antihistamine spray on those worst nights?
  • greg208: I haven’t mixed it yet but will give it a shot. How much 9 % saline do you add per spray? And did you use a particular brand or size? Also, did the dilution change how long the anxiolytic effect lasted or feel any weaker? Will test the mix and let you know how it goes.
  • greg208: Not gonna lie, the saline idea sounds spot on – I’ll grab a gentle nasal spray and rinse right before the Selank each session, start with just the 300 µg dose and a silicone bottle if I can. I’m curious though, how long did you wait after rinsing before spraying? Also, will the antihistamine work long‑term or just a one‑off for the worst nights?
  • greg208: Thanks kayla, that makes sense – the 9 % salt rinse and a slower‑pressure device sound like good moves. 9 % saline first, then switch to the gentler spray kit I’ve got. Do youCaptain use any particular timing to minimise the sting, like a pause before each puff? I’m keen to see if that trick cuts the run‑ny-ness.

Community discussion - research and educational context only. Not medical advice.