Thinking about a low‑dose rapamycin pulse – how often should I do it?

Posted by greg208 in Longevity & Anti-Aging - 1 points, 0 comments.

I’ve read that low‑dose (3‑6 mg) rapamycin once a week can boost autophagy and mimic a calorie‑restriction effect without the big side‑effects of daily use. I’m 42, a retired firefighter, still lifting a bit and trying to keep my joints in shape. I’m new to this whole peptide world, so before I line up a prescription I’d love to hear from people who’ve tried a weekly pulse.

How often do you end up doing it? Do you wait a full week or mix it in with another week of “off” to keep the immune system from dropping? I’ve heard about mouth sores and a bit of lipid rise – anything I should check with a doctor or a regular blood test?

Also, I’m looking at a spermidine supplement for extra autophagy support – any thoughts on timing or order? Thanks in advance for your honest experience; I’m not looking for a cure, just a realistic protocol that keeps the body fighting ageing without making me feel ill.

Community discussion - research and educational context only. Not medical advice.