GHRP-6 vs Tesamorelin
A side-by-side research comparison of GHRP-6 and Tesamorelin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | GHRP-6 | Tesamorelin |
|---|---|---|
| Full name | Growth Hormone Releasing Peptide-6 | Tesamorelin Acetate (Egrifta) |
| Category | Growth Hormone | Growth Hormone |
| Status | Research compound | FDA Approved |
| Mechanism | Activates GHSR-1a on pituitary for GH release and hypothalamic neurons for appetite. Triggers gastric motility and ghrelin-like reward signaling. | Binds pituitary GHRH receptors with enhanced affinity via hexenoic acid modification. Effective at mobilizing visceral fat via GH-mediated lipolysis. |
| Molecular weight | 873 Da | 5,136 Da |
| Half-life | 2-3 hours | 26-38 minutes |
| Bioavailability | High (SubQ) | High (SubQ) |
| Typical dose | 100-300 mcg | 2 mg |
| Frequency | 2-3x daily | Once daily |
| Route | Subcutaneous | Subcutaneous injection |
GHRP-6 reported benefits
- Strong GH release
- Powerful appetite stimulation
- Gastric motility improvement
- Recovery enhancement
- Gut healing support
Tesamorelin reported benefits
- Visceral fat reduction (up to 18%)
- FDA-approved safety
- Improved lipid panels
- Cognitive benefits (emerging)
- No significant IGF-1 overshoot
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Research and educational reference only. Not medical advice.