Enclomiphene vs Testosterone Cypionate
A side-by-side research comparison of Enclomiphene and Testosterone Cypionate across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Enclomiphene | Testosterone Cypionate |
|---|---|---|
| Full name | Enclomiphene Citrate | Testosterone Cypionate (Depo-Testosterone) |
| Category | Hormone Replacement | Hormone Replacement |
| Status | Investigational drug | FDA Approved (Schedule III) |
| Mechanism | Blocks estrogen receptors in the hypothalamus, reducing negative feedback and increasing GnRH pulsatility, which stimulates LH and FSH release for endogenous testosterone production. | Exogenous testosterone binds androgen receptors in muscle, bone, brain, and reproductive tissues. The cypionate ester provides slow release from the injection depot, maintaining physiologic levels between doses. |
| Molecular weight | 598.09 Da | 412.61 Da |
| Half-life | 10-14 hours | ~8 days |
| Bioavailability | ~50% oral | ~100% (intramuscular) |
| Typical dose | 12.5-25 mg | 100-200 mg |
| Frequency | Daily | Weekly or split biweekly |
| Route | Oral capsule | Intramuscular or subcutaneous injection |
Enclomiphene reported benefits
- Increased endogenous testosterone
- Preserved fertility
- Improved libido
- Enhanced energy and mood
- No testicular atrophy
Testosterone Cypionate reported benefits
- Restored libido and sexual function
- Increased lean muscle mass
- Improved bone density
- Enhanced mood and cognitive clarity
- Reduced visceral fat
- Improved energy and motivation
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Research and educational reference only. Not medical advice.