DMT vs Salvinorin A
A side-by-side research comparison of DMT and Salvinorin A across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | DMT | Salvinorin A |
|---|---|---|
| Full name | N,N-Dimethyltryptamine | Salvinorin A (Salvia divinorum) |
| Category | Psychedelics | Psychedelics |
| Status | Schedule I (research compound) | Varies by region; research compound |
| Mechanism | Activates serotonin 5-HT2A receptors, producing vivid changes in perception. When taken orally in ayahuasca, an MAO inhibitor is needed so it is not broken down too quickly. | Activates kappa-opioid receptors (not serotonin receptors), which makes its effects unlike LSD or psilocybin. |
| Molecular weight | 188.27 g/mol | 432.46 g/mol |
| Half-life | ~10-15 minutes | Very short |
| Bioavailability | Inhaled/injected (very short); oral only with an MAO inhibitor | Oral |
| Typical dose | Controlled dosing in clinical studies | Varies by individual and setting |
| Frequency | One to a few supervised sessions | Occasional |
| Route | Inhalation or IV in research; oral as ayahuasca | Smoked, vaporized or held in the mouth |
DMT reported benefits
- Studied for depression
- Very short experience aids research design
- Used to study consciousness
- Long traditional use as ayahuasca
Salvinorin A reported benefits
- Unique kappa-opioid mechanism
- Very short experience
- Long traditional Mazatec use
- Of interest for depression research
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Research and educational reference only. Not medical advice.