Ayahuasca vs Psilocin
A side-by-side research comparison of Ayahuasca and Psilocin across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | Ayahuasca | Psilocin |
|---|---|---|
| Full name | Ayahuasca (DMT + MAO inhibitor brew) | 4-Hydroxy-DMT (active form of psilocybin) |
| Category | Psychedelics | Psychedelics |
| Status | Traditional/ceremonial; research compound | Schedule I (research compound) |
| Mechanism | The MAO-inhibiting vine (harmine and related compounds) stops the body from breaking down DMT, allowing an oral psychedelic experience that activates serotonin 5-HT2A receptors. | Directly activates serotonin 5-HT2A receptors. Psilocybin is a "prodrug" that the body converts into psilocin. |
| Molecular weight | Mixture (no single value) | 204.27 g/mol |
| Half-life | Several hours (extended by MAO inhibition) | ~1-3 hours |
| Bioavailability | Oral | Oral |
| Typical dose | Brew-based, varies by preparation | Varies by individual and setting |
| Frequency | Ceremonial or occasional study sessions | Occasional |
| Route | Oral brew | Oral |
Ayahuasca reported benefits
- Studied for treatment-resistant depression
- Explored for grief and trauma
- Long history of ceremonial use
- May produce lasting shifts in outlook
Psilocin reported benefits
- The active form behind psilocybin
- Studied for depression and anxiety
- Faster onset than psilocybin
- Classic serotonergic psychedelic
Related comparisons
Research and educational reference only. Not medical advice.