5-MeO-DMT vs LSA
A side-by-side research comparison of 5-MeO-DMT and LSA across mechanism, dosing, half-life, benefits, side effects and research status.
Comparison table
| Attribute | 5-MeO-DMT | LSA |
|---|---|---|
| Full name | 5-Methoxy-N,N-dimethyltryptamine | Ergine / D-lysergic acid amide (morning glory, Hawaiian baby woodrose) |
| Category | Psychedelics | Psychedelics |
| Status | Schedule I (research compound) | Natural ergot alkaloid; some seeds legal |
| Mechanism | Strongly activates serotonin 5-HT1A and 5-HT2A receptors, producing rapid and intense changes in consciousness. | Acts on serotonin and adrenergic receptors; less potent and more sedating than LSD. |
| Molecular weight | 218.30 g/mol | 267.33 g/mol |
| Half-life | Short (minutes) | Several hours |
| Bioavailability | Inhaled/injected | Oral |
| Typical dose | Low milligram range in clinical studies | Varies by individual and setting |
| Frequency | One to a few supervised sessions | Occasional |
| Route | Inhalation or injection in research settings | Oral |
5-MeO-DMT reported benefits
- Studied for treatment-resistant depression
- Short duration suits clinical use
- Explored for anxiety
- Rapid onset of effects
LSA reported benefits
- Naturally occurring lysergamide
- Found in common seeds
- Dreamy, introspective effects
- Long traditional use
Related comparisons
Research and educational reference only. Not medical advice.