Anti-inflammatory peptides in research - BPC-157, KPV, LL-37, thymosin alpha-1 and protocols for reducing systemic inflammation.
A pentadecapeptide derived from human gastric juice that promotes wound healing and tissue repair. Demonstrates remarkable regenerative properties across multiple tissue types including tendon, muscle
Dose: 250-500 mcg per dose | Route: Subcutaneous injection (or oral capsules)
A tripeptide derived from alpha-MSH with potent anti-inflammatory properties. Shows promise for gut inflammation, skin conditions, and immune modulation without melanogenic effects.
Dose: 200-500 mcg per dose | Route: Oral, topical, or subcutaneous
A human cathelicidin antimicrobial peptide with broad-spectrum activity against bacteria, viruses, and fungi. Also promotes wound healing and modulates innate immune response.
Dose: 50-100 mcg | Route: Topical or subcutaneous injection
A thymic peptide approved in over 35 countries for immune modulation. Enhances T-cell function, dendritic cell maturation, and anti-viral/anti-tumor immunity without overstimulation.
Dose: 1.6-3.2 mg | Route: Subcutaneous injection
Read full Thymosin Alpha-1 guide →
At 1-4.5mg (vs standard 50mg), naltrexone briefly blocks opioid receptors, causing a rebound upregulation of endorphins and enkephalins. Widely prescribed by telemedicine clinics for autoimmune condit
Dose: 1.5-4.5 mg | Route: Oral capsule (compounded)
Read full Low-Dose Naltrexone (LDN) guide →
An endogenous fatty acid amide that modulates the endocannabinoid system without directly binding CB receptors. Produces analgesic, anti-inflammatory, and neuroprotective effects through the "ent
Dose: 300-1200 mg | Route: Oral (micronized preferred)
A topical NSAID that delivers potent anti-inflammatory and analgesic effects directly to the site of pain without significant systemic absorption. Ideal for joint, tendon, and muscle pain with minimal
Dose: 4g gel (1% or 2%) per joint | Route: Topical gel
Read full Diclofenac Topical guide →
A semi-synthetic heparin-like polysaccharide with disease-modifying properties for osteoarthritis. Stimulates proteoglycan synthesis, inhibits cartilage-degrading enzymes, and improves synovial fluid
Dose: 2-3 mg/kg SC (veterinary extrapolation) or 100mg oral 3x/day | Route: Subcutaneous injection or oral capsule
Read full Pentosan (Joint Pain) guide →
An 11-amino-acid peptide derived from erythropoietin (EPO) that targets the innate repair receptor without the blood-cell-stimulating (erythropoietic) effects of EPO. Investigated for neuropathic pain
Dose: 1-4 mg per dose | Route: Subcutaneous injection
A standardized extract of Boswellia serrata (frankincense) whose active constituent AKBA provides a non-NSAID anti-inflammatory pathway. Biohackers use it for joint pain, gut inflammation, and as a na
Dose: 100-250 mg AKBA-standardized, 1-2x daily | Route: Oral capsule
Read full Boswellia (AKBA) guide →
A short synthetic peptide bioregulator from the Khavinson family targeted at cartilage and connective/musculoskeletal tissue. Used in the bioregulator community for joint and cartilage support in shor
Dose: ~1-2 capsules/day or short injectable courses | Route: Oral capsule or subcutaneous
A naturally occurring opioid heptapeptide originally isolated from the skin of South American frogs. It is an extremely potent mu-opioid agonist studied for analgesia, and is included here strictly fo
Dose: Not established for human use | Route: Injection (research)